The siege of Den Bosch was begun on april 30, 1629 the siege and the conquest of the city by the forces of the Dutch Republic under the leadership of Frederick Henry, Prince of Orange, the city and the surrounding area soaked off of the old Duchy Brabant. After a siege that lasts about four and a half months, Frederick Henry on september 17, with his troops in the city.
Two days later, the first reformed service place in the Sint-Jan in presence of Frederick Henry and his wife Amalia of Solms-Braunfels. It is the beginning of a great turning point in the history of the city and the Cathedral. A century and a half was the Bosch people the right to self-government and representation in the States General. Of any free exercise of the Catholic faith in 1629 could no longer are all male clergy within two months had to leave the city.
The church property, fixed-to the States General with the exception of the ecclesiastical ornaments that the expelled clergy should take. From 1629 until 1813, the Sint-Jan as prayer house for the Dutch Reformed Church. About a fifth of the population was Protestant in this period the rest remained Catholic and were at this time for the exercise of their religion rely on churches.
After the capitulation of Den Bosch on 14 december 1629 continued the Bossche Brotherhood existence she was not raised. In 1641 the Governor asked van Zyl Wolfert van Brederode and some others who were among the new Protestant upper layer to become a member of the Bossche Lieve Vrouwe Broederschap. For that time was that a very unusual step because Catholics and Protestants would be a member of one association. Within the brotherhood created a heated debate and there had to be voted with 28 against 23 votes, it was decided to allow Protestants and out came new statutes. In it was as a reason for the opening of the brotherhood for Protestants specified that it was undesirable that Catholic and Protestant notables so hostile. Organizational changed also the outside members were abolished and there would be from now on, 18 Catholic and Protestant members 18. A group of Orthodox preachers including Reverend Voetius was furious about the conversion of the fraternity and that took care of violent polemics in which many were concerned. Finally made the States of Bolting in 1646 put an end to the squabbling the statutes of the Brotherhood remained as they were drawn up in 1642 a Ecumenical thinking that was far ahead of his time. In 1818 they invited the Prince of orange the later King William II to Swans brother. Since then, many members of the Royal